Raskaudenaikainen kannabiksen käyttö aiheuttaa syntyvälle lapselle psyykkisiä ongelmia
Tuore JAMA Psychiatryn artikkeli paljastaa lisää jo entuudestaan haitallisen kannabiksen
huonoja vaikutuksia
Paul S et al (2020)
Associations Between Prenatal Cannabis Exposure and Childhood Outcomes
- Results From the ABCD Study
IMPORTANCE
In light of increasing cannabis use among pregnant women, the US Surgeon
General recently issued an advisory against the use of marijuana during pregnancy.
OBJECTIVE
To evaluate whether cannabis use during pregnancy is associated with adverse
outcomes among offspring.
DESIGN, SETTING, AND PARTICIPANTS
In this cross-sectional study, datawere obtained from
the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development
Study, which recruited 11 875 children aged 9 to 11 years, as well as a parent or caregiver, from
22 sites across the United States between June 1, 2016, and October 15, 2018.
EXPOSURE Prenatal cannabis exposure prior to and after maternal knowledge of pregnancy.
MAIN OUTCOMES AND MEASURES
Symptoms of psychopathology in children (ie, psychotic-like
experiences [PLEs] and internalizing, externalizing, attention, thought, and social problems),
cognition, sleep, birth weight, gestational age at birth, body mass index, and brain structure
(ie, total intracranial volume, white matter volume, and gray matter volume).
Covariates included familial (eg, income and familial psychopathology), pregnancy (eg, prenatal
exposure to alcohol and tobacco), and child (eg, substance use) variables.
RESULTS Among 11 489 children (5997 boys [52.2%]; mean [SD] age, 9.9 [0.6] years) with
nonmissing prenatal cannabis exposure data, 655 (5.7%) were exposed to cannabis
prenatally. Relative to no exposure, cannabis exposure only before (413 [3.6%]) and after
(242 [2.1%]) maternal knowledge of pregnancy were associated with greater offspring
psychopathology characteristics (ie, PLEs and internalizing, externalizing, attention, thought
and, social problems), sleep problems, and body mass index, as well as lower cognition and
gray matter volume (all |β| > 0.02; all false discovery rate [FDR]–corrected P < .03).
Only exposure after knowledge of pregnancy was associated with lower birth weight as well as
total intracranial volume and white matter volumes relative to no exposure and exposure
only before knowledge (all |β| > 0.02; all FDR-corrected P < .04). When including potentially
confounding covariates, exposure after maternal knowledge of pregnancy remained
associated with greater PLEs and externalizing, attention, thought, and social problems
(all β > 0.02; FDR-corrected P < .02).
Exposure only prior to maternal knowledge of pregnancy did not differ from no exposure on
any outcomes when considering potentially confounding variables (all |β| < 0.02; FDR-corrected P > .70).
CONCLUSIONS AND RELEVANCE
This study suggests that prenatal cannabis exposure and its correlated factors are associated
with greater risk for psychopathology during middle childhood.
Cannabis use during pregnancy should be discouraged.
ref:
JAMA Psychiatry. doi:10.1001/jamapsychiatry.2020.2902
Published online September 23, 2020.
huonoja vaikutuksia
Paul S et al (2020)
Associations Between Prenatal Cannabis Exposure and Childhood Outcomes
- Results From the ABCD Study
IMPORTANCE
In light of increasing cannabis use among pregnant women, the US Surgeon
General recently issued an advisory against the use of marijuana during pregnancy.
OBJECTIVE
To evaluate whether cannabis use during pregnancy is associated with adverse
outcomes among offspring.
DESIGN, SETTING, AND PARTICIPANTS
In this cross-sectional study, datawere obtained from
the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development
Study, which recruited 11 875 children aged 9 to 11 years, as well as a parent or caregiver, from
22 sites across the United States between June 1, 2016, and October 15, 2018.
EXPOSURE Prenatal cannabis exposure prior to and after maternal knowledge of pregnancy.
MAIN OUTCOMES AND MEASURES
Symptoms of psychopathology in children (ie, psychotic-like
experiences [PLEs] and internalizing, externalizing, attention, thought, and social problems),
cognition, sleep, birth weight, gestational age at birth, body mass index, and brain structure
(ie, total intracranial volume, white matter volume, and gray matter volume).
Covariates included familial (eg, income and familial psychopathology), pregnancy (eg, prenatal
exposure to alcohol and tobacco), and child (eg, substance use) variables.
RESULTS Among 11 489 children (5997 boys [52.2%]; mean [SD] age, 9.9 [0.6] years) with
nonmissing prenatal cannabis exposure data, 655 (5.7%) were exposed to cannabis
prenatally. Relative to no exposure, cannabis exposure only before (413 [3.6%]) and after
(242 [2.1%]) maternal knowledge of pregnancy were associated with greater offspring
psychopathology characteristics (ie, PLEs and internalizing, externalizing, attention, thought
and, social problems), sleep problems, and body mass index, as well as lower cognition and
gray matter volume (all |β| > 0.02; all false discovery rate [FDR]–corrected P < .03).
Only exposure after knowledge of pregnancy was associated with lower birth weight as well as
total intracranial volume and white matter volumes relative to no exposure and exposure
only before knowledge (all |β| > 0.02; all FDR-corrected P < .04). When including potentially
confounding covariates, exposure after maternal knowledge of pregnancy remained
associated with greater PLEs and externalizing, attention, thought, and social problems
(all β > 0.02; FDR-corrected P < .02).
Exposure only prior to maternal knowledge of pregnancy did not differ from no exposure on
any outcomes when considering potentially confounding variables (all |β| < 0.02; FDR-corrected P > .70).
CONCLUSIONS AND RELEVANCE
This study suggests that prenatal cannabis exposure and its correlated factors are associated
with greater risk for psychopathology during middle childhood.
Cannabis use during pregnancy should be discouraged.
ref:
JAMA Psychiatry. doi:10.1001/jamapsychiatry.2020.2902
Published online September 23, 2020.