Rauhoittavien ja unilääkkeiden käyttö hyvin todennäköisesti lisää vanhusten dementiaa
Rauhoittavien ja unilääkkeiden käyttö hyvin todennäköisesti lisää vanhusten dementiaa
Abstract
Objective To evaluate the association between use of benzodiazepines
and incident dementia.
Design Prospective, population based study.
Setting PAQUID study, France.
Participants 1063 men and women (mean age 78.2 years) who were
free of dementia and did not start taking benzodiazepines until at least
the third year of follow-up.
Main outcome measures Incident dementia, confirmed by a neurologist.
Results
During a 15 year follow-up, 253 incident cases of dementia
were confirmed.
New use of benzodiazepines was associated with an
increased risk of dementia (multivariable adjusted hazard ratio 1.60,
95% confidence interval 1.08 to 2.38).
Sensitivity analysis consideringthe existence of depressive symptoms showed a similar association
(hazard ratio 1.62, 1.08 to 2.43). A secondary analysis pooled cohorts
of participants who started benzodiazepines during follow-up and
evaluated the association with incident dementia. The pooled hazard
ratio across the five cohorts of new benzodiazepine users was 1.46 (1.10
to 1.94).
Results of a complementary nested case-control study showed
that ever use of benzodiazepines was associated with an approximately
50% increase in the risk of dementia (adjusted odds ratio 1.55, 1.24 to
1.95) compared with never users.
The results were similar in past users (odds ratio 1.56, 1.23 to 1.98) and
recent users (1.48, 0.83 to 2.63) but reached significance only for past users.
Conclusions
In this prospective population based study, new use of
benzodiazepines was associated with increased risk of dementia.
The result was robust in pooled analyses across cohorts of new users of
benzodiazepines throughout the study and in a complementary
case-control study.
Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should
be cautioned against.
koko tutkimus löytyy:
www.bmj.com/highwire/filestream/604990/field_highwire_article_pdf/0/bmj.e6231
Abstract
Objective To evaluate the association between use of benzodiazepines
and incident dementia.
Design Prospective, population based study.
Setting PAQUID study, France.
Participants 1063 men and women (mean age 78.2 years) who were
free of dementia and did not start taking benzodiazepines until at least
the third year of follow-up.
Main outcome measures Incident dementia, confirmed by a neurologist.
Results
During a 15 year follow-up, 253 incident cases of dementia
were confirmed.
New use of benzodiazepines was associated with an
increased risk of dementia (multivariable adjusted hazard ratio 1.60,
95% confidence interval 1.08 to 2.38).
Sensitivity analysis consideringthe existence of depressive symptoms showed a similar association
(hazard ratio 1.62, 1.08 to 2.43). A secondary analysis pooled cohorts
of participants who started benzodiazepines during follow-up and
evaluated the association with incident dementia. The pooled hazard
ratio across the five cohorts of new benzodiazepine users was 1.46 (1.10
to 1.94).
Results of a complementary nested case-control study showed
that ever use of benzodiazepines was associated with an approximately
50% increase in the risk of dementia (adjusted odds ratio 1.55, 1.24 to
1.95) compared with never users.
The results were similar in past users (odds ratio 1.56, 1.23 to 1.98) and
recent users (1.48, 0.83 to 2.63) but reached significance only for past users.
Conclusions
In this prospective population based study, new use of
benzodiazepines was associated with increased risk of dementia.
The result was robust in pooled analyses across cohorts of new users of
benzodiazepines throughout the study and in a complementary
case-control study.
Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should
be cautioned against.
koko tutkimus löytyy:
www.bmj.com/highwire/filestream/604990/field_highwire_article_pdf/0/bmj.e6231