Runsas kannabiksenkäyttö raskausaikana- syntyvän lapsen syntymäpaino 200 g pienempi. Riskitekijä pikkulapsikuolemiin, kroonisten sairauksien kehittymiselle sekä kasvun ja kognitiivisen kehityksen häiriöille
Runsas kannabiksenkäyttö raskausaikana pienentää syntyvän lapsen syntymäpainoa 200 grammalla, mikä on riskitekijä pikkulapsikuolemiin, kroonisten sairauksien kehittymiseen sekä kasvun ja kognitiivisen kehityksen häiriöihin
Runsas kannabiksenkäyttö raskausaikana pienentää syntyvän lapsen syntymäpainoa 200 grammalla, vielä sen jälkeen, kun tupakoinnin sekoittava vaikutus on huomioitu.
Odottavan äidin kannabiksen käyttö on yhteydessä pienentyneeseen syntymäpainoon, joka on taas yhteydessä seuraaviin asioihin: riskitekijä pikkulapsikuolemiin, kroonisten sairauksien kehittymiseen sekä kasvun ja kognitiivisen kehityksen häiriöihin.
Myös isän kannabiksen käyttö tekee epigeneettisiä muutoksia siittiöihin, joiden vaikutuksia ei vielä riittävästi tunneta. Jos mies haluaa syntyvälle lapselle mahdollisimman hyvät lähtökohdat, niin hän pidättäytyy kolme kuukautta ennen hedelmöityshetkeä kaikista päihteistä. Joidenkin arvioiden mukaan noin 50% suomalaisista siitetään humalassa.
Sitaatit suoraan tutkimuksesta:
The study below posits that “about 3–4% of pregnant women in the US and southern Europe have reported cannabis use in pregnancy.
…
In general, women who do not abstain from cannabis in pregnancy are also engaged in other risky behaviors such as alcohol and tobacco use.
Cannabis use during pregnancy raises concerns because prenatal cannabis exposure may be associated with adverse birth outcomes.
…
In the “Generation R” Study, data on fetal growth obtained by ultrasounds showed that cannabis
use during pregnancy was associated with growth restrictions in mid- and late pregnancy. Furthermore, a meta-analysis [15] concluded that infants exposed in utero
to cannabis had lower birth weight, but not shorter birth length or smaller head circumference.
…
However, recent research suggests that regular use of cannabis in men causes epigenetic changes in sperm cells, and paternal cannabis use during pregnancy has, potentially, further epigenetic effects.
…
However, after maternal prolonged cannabis use, children had a lower mean birth weight of approximately 200 g, even after adjusting for important confounders as for instance smoking.
…
Rates of cannabis use among pregnant women are increasing.
This study indicates that long-term cannabis use in pregnancy results in reduced birth weight of the newborn, a worrying effect since low birth weight may have negative at-birth as well as long-term consequences for the child, such as a risk factor of neonatal and infant death, development of chronic disease, and growth and cognitive disorders.
Pregnant women and those considering becoming pregnant should be advised to avoid using cannabis.
Clinicians should screen not only for cannabis use but also for the length and intensity of use as part of a comprehensive substance use screening. In addition, pregnant women should be advised that cutting down the use of cannabis during pregnancy is beneficial as opposed to continuous use of cannabis while pregnant”
Gabrhelik R et al
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes:
A Longitudinal Cohort Study
Abstract
Background: With recent changes in legislation regulating
recreational and medical cannabis use around the globe, increased
use in pregnancy is to be expected.
Objectives: To investigate the association between cannabis use during
pregnancy and birth outcomes.
Method: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective
pregnancy cohort, were used. Participants were recruited
from all over Norway between 1999 and 2008: 9,312
women with 10,373 pregnancies who reported use of cannabis
before or in pregnancy. Women reported on their illegal
drug use before pregnancy and at pregnancy weeks
17/18 and 30 and at 6 months postpartum. Linear regression
was used to estimate crude and adjusted effects of prenatal
cannabis exposure on birth outcomes.
Results: In 10,101 pregnancies, women had used cannabis
before pregnancybut not during pregnancy. In 272 pregnancies,
women hadused cannabis during pregnancy, and among these, in 63
pregnancies, women had used cannabis in at least 2 periods.
In adjusted analyses for potential confounders, only cannabis
use during at least 2 periods of pregnancy showed statistically
significant effects on birth weight. The effect was observed
in the complete cohort (B = −228 g, 95% CI = −354 to
−102, p < 0.001) and for the subgroup where information
about the child’s father was available (B = −225 g, 95% CI =
−387 to −63, p = 0.01).
Our results may indicate that prolonged
use causes more harm, whereas short-term use did
not indicate adverse effects on birth outcomes.
Conclusions:
There was a statistically significant and clinically relevant association
between the use of cannabis during pregnancy and reduced birth weight.
Clinicians should screen not only for cannabis use but also for the length
and intensity of use as part of a comprehensive substance use screening.
In 2015, the American College of Obstetricians and Gynecologists issued
a committee opinion discouraging physicians from suggesting use
of cannabis during preconception, pregnancy, and lactation.
Ref: Gabrhelik R et al
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes:
A Longitudinal Cohort Study,
Eur Addict Res 11, DOI: 10.1159/000510821
Published online: October 9, 2020
Runsas kannabiksenkäyttö raskausaikana pienentää syntyvän lapsen syntymäpainoa 200 grammalla, vielä sen jälkeen, kun tupakoinnin sekoittava vaikutus on huomioitu.
Odottavan äidin kannabiksen käyttö on yhteydessä pienentyneeseen syntymäpainoon, joka on taas yhteydessä seuraaviin asioihin: riskitekijä pikkulapsikuolemiin, kroonisten sairauksien kehittymiseen sekä kasvun ja kognitiivisen kehityksen häiriöihin.
Myös isän kannabiksen käyttö tekee epigeneettisiä muutoksia siittiöihin, joiden vaikutuksia ei vielä riittävästi tunneta. Jos mies haluaa syntyvälle lapselle mahdollisimman hyvät lähtökohdat, niin hän pidättäytyy kolme kuukautta ennen hedelmöityshetkeä kaikista päihteistä. Joidenkin arvioiden mukaan noin 50% suomalaisista siitetään humalassa.
Sitaatit suoraan tutkimuksesta:
The study below posits that “about 3–4% of pregnant women in the US and southern Europe have reported cannabis use in pregnancy.
…
In general, women who do not abstain from cannabis in pregnancy are also engaged in other risky behaviors such as alcohol and tobacco use.
Cannabis use during pregnancy raises concerns because prenatal cannabis exposure may be associated with adverse birth outcomes.
…
In the “Generation R” Study, data on fetal growth obtained by ultrasounds showed that cannabis
use during pregnancy was associated with growth restrictions in mid- and late pregnancy. Furthermore, a meta-analysis [15] concluded that infants exposed in utero
to cannabis had lower birth weight, but not shorter birth length or smaller head circumference.
…
However, recent research suggests that regular use of cannabis in men causes epigenetic changes in sperm cells, and paternal cannabis use during pregnancy has, potentially, further epigenetic effects.
…
However, after maternal prolonged cannabis use, children had a lower mean birth weight of approximately 200 g, even after adjusting for important confounders as for instance smoking.
…
Rates of cannabis use among pregnant women are increasing.
This study indicates that long-term cannabis use in pregnancy results in reduced birth weight of the newborn, a worrying effect since low birth weight may have negative at-birth as well as long-term consequences for the child, such as a risk factor of neonatal and infant death, development of chronic disease, and growth and cognitive disorders.
Pregnant women and those considering becoming pregnant should be advised to avoid using cannabis.
Clinicians should screen not only for cannabis use but also for the length and intensity of use as part of a comprehensive substance use screening. In addition, pregnant women should be advised that cutting down the use of cannabis during pregnancy is beneficial as opposed to continuous use of cannabis while pregnant”
Gabrhelik R et al
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes:
A Longitudinal Cohort Study
Abstract
Background: With recent changes in legislation regulating
recreational and medical cannabis use around the globe, increased
use in pregnancy is to be expected.
Objectives: To investigate the association between cannabis use during
pregnancy and birth outcomes.
Method: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective
pregnancy cohort, were used. Participants were recruited
from all over Norway between 1999 and 2008: 9,312
women with 10,373 pregnancies who reported use of cannabis
before or in pregnancy. Women reported on their illegal
drug use before pregnancy and at pregnancy weeks
17/18 and 30 and at 6 months postpartum. Linear regression
was used to estimate crude and adjusted effects of prenatal
cannabis exposure on birth outcomes.
Results: In 10,101 pregnancies, women had used cannabis
before pregnancybut not during pregnancy. In 272 pregnancies,
women hadused cannabis during pregnancy, and among these, in 63
pregnancies, women had used cannabis in at least 2 periods.
In adjusted analyses for potential confounders, only cannabis
use during at least 2 periods of pregnancy showed statistically
significant effects on birth weight. The effect was observed
in the complete cohort (B = −228 g, 95% CI = −354 to
−102, p < 0.001) and for the subgroup where information
about the child’s father was available (B = −225 g, 95% CI =
−387 to −63, p = 0.01).
Our results may indicate that prolonged
use causes more harm, whereas short-term use did
not indicate adverse effects on birth outcomes.
Conclusions:
There was a statistically significant and clinically relevant association
between the use of cannabis during pregnancy and reduced birth weight.
Clinicians should screen not only for cannabis use but also for the length
and intensity of use as part of a comprehensive substance use screening.
In 2015, the American College of Obstetricians and Gynecologists issued
a committee opinion discouraging physicians from suggesting use
of cannabis during preconception, pregnancy, and lactation.
Ref: Gabrhelik R et al
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes:
A Longitudinal Cohort Study,
Eur Addict Res 11, DOI: 10.1159/000510821
Published online: October 9, 2020